Midtown Manhattan, or simply Midtown, is a geographic area of Manhattan, New York City. It is home to some of the city's most iconic buildings, including the Empire State Building, the Chrysler Building, and the United Nations Headquarters. It contains world-famous commercial zones such as Rockefeller Center, Broadway, and Times Square.

Geographically, Midtown is commonly defined as the area south of 59th Street, east of the Hudson River, west of the East River, and though its southern border is less clear, most consider it to be somewhere between 14th Street and 30th Street. Overall, Manhattan can be divided into three geographic regions: "Uptown", Midtown, and "Downtown".

As New York's largest central business district, Midtown Manhattan is the busiest single commercial district in the United States, and among the most intensely used pieces of real estate in the world. The majority of New York City's skyscrapers, including its tallest hotels and apartment towers, lie within Midtown. The area hosts commuters and residents working in its offices, hotels, and retail establishments; many tourists, visiting residents, and students populate the district. Some areas, such as Times Square and Fifth Avenue, have large clusters of retail stores. Sixth Avenue in Midtown holds the headquarters of three of the four major television networks. It is a growing center of finance, second in importance within the United States only to Downtown Manhattan's Financial District. Times Square is the center of Broadway theatre.